News Ticker

LabBook June 20, 2014

Faculty and staff members at University of Chicago Medicine spent time this week participating in a city-wide disaster drill. Here, members of the Radiation Safety team stand outside a decontamination trailer, awaiting mock patients on Thursday, June 19.

Faculty and staff members at University of Chicago Medicine spent time this week participating in a city-wide disaster drill. Here, members of the Radiation Safety team stand outside a decontamination trailer, awaiting mock patients on Thursday, June 19.

This week’s rundown of recent research publications of note from University of Chicago scientists and physicians:

Effect of selumetinib vs chemotherapy on progression-free survival in uveal melanoma: a randomized clinical trial, including Thomas F. Gajewski, MD, PhD – The Journal of the American Medical Association

From the abstract: “In this hypothesis-generating study of patients with advanced uveal melanoma, selumetinib compared with chemotherapy resulted in a modestly improved progression-free survival and response rate; however, no improvement in overall survival was observed. Improvement in clinical outcomes was accompanied by a high rate of adverse events.”

Effect of telomere length on survival in patients with idiopathic pulmonary fibrosis: an observational cohort study with independent validation, including Imre Noth, MD – The Lancet Respiratory Medicine

From the abstract: “Short telomere lengths are found in a subset of patients with idiopathic pulmonary fibrosis, but their clinical significance is unknown. Our aim was to investigate whether patients with various blood leucocyte telomere lengths had different overall survival.”

BK Virus and Its Role in Hematopoietic Stem Cell Transplantation: Evolution of a Pathogen, Jennifer delaCruz, MD, and Kenneth Pursell, MD – Current Infectious Disease Report

From the abstract: “We reviewed the literature regarding disease induced by BK virus (BKV) in the hematopoietic stem cell transplant (HSCT) population, particularly hemorrhagic cystitis (HC) and nephritis. The association between BKV and HC has been reported over the past four decades. BKV has been clinically implicated and widely accepted as an etiologic agent of HC and nephritis in HSCT and nephropathy in renal transplant patients. We discuss the potential benefit of early initiation of therapy in patients who fail supportive care alone as well as the different treatment strategies for HC induced by BKV. Treatments that have been used such as cidofovir and leflunomide are accompanied by risks, and the benefits are not as concrete as with other viral illness in the HSCT population.”

Sugar Sweetened Beverage Intake and Cancer Recurrence and Survival in CALGB 89803 (Alliance), including Hedy Lee Kindler, MD – PLoS One

From the abstract: “In colon cancer patients, obesity, sedentary lifestyle, and high dietary glycemic load have been associated with increased risk of cancer recurrence. High sugar-sweetened beverage intake has been associated with obesity, diabetes, and cardio-metabolic diseases, but the influence on colon cancer survival is unknown. We assessed the association between sugar-sweetened beverage consumption on cancer recurrence and mortality in 1,011 stage III colon cancer patients who completed food frequency questionnaires as part of a U.S. National Cancer Institute-sponsored adjuvant chemotherapy trial. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with Cox proportional hazard models.”

Follow

Get every new post delivered to your Inbox.

Join 1,337 other followers

%d bloggers like this: