Argonne

Mercy, Mercy, MRSA

In her 2010 book, Superbug: The Fatal Menace of MRSA, author and self-proclaimed “disease geek” Maryn McKenna charted the steady advance of a treatment-resistant organism which she referred to as a “crisis in many dimensions.” MRSA illustrates “failures of science, failures of the marketplace, and failures of support for research and innovation,” McKenna wrote. Since […]

LabBook June 22, 2012

Welcome to LabBook, our weekly roundup of University of Chicago Medicine & Biological Sciences research news from around campus and the world wide web. Each Friday, LabBook will recap the week on the blog, link to news stories about our faculty and studies, and briefly summarize a handful of recent publications by our researchers. THIS […]

A New Model for Anxiety…and More

by Rob Mitchum An advantage and disadvantage of hypothesis-free studies looking for genes associated with various traits or diseases is that they often point to genetic candidates that don’t make immediate sense. One example of this occurrence was the 2005 discovery of an association between the gene Glo1 and anxiety-like behaviors in mice. Previously, scientists […]

Hacking the Brain’s Security System

by Rob Mitchum The brain is a privileged organ, afforded protections denied to all the other organs of the body. Though the circulatory system functions much the same way above and below the neck, using blood to exchange nourishment for waste with cells, the exchange is conducted under much heavier security in the central nervous […]

The Secret Origin of the Vertebrate Brain

By Rob Mitchum The acorn worm is an eye-less, ear-less invertebrate that lives in the intertidal zone, scavenging food particles from the sand and water. One wouldn’t expect to find the developmental clues for the creation of the vertebrate brain in such a humble creature. But a new study led by a University of Chicago […]

A Nano-Vehicle to Fight Brain Cancer

By Rob Mitchum Treating a brain tumor in a lab dish is easy. Scientists have developed a full arsenal of treatments to kill tumor cells, using natural toxins, chemotherapeutic drugs, and even gene therapy to send them to an early grave. But making those therapies work in the actual setting of the brain is a […]

Evolution and the Unraveling of DNA

By Rob Mitchum In cells, DNA doesn’t often hang out in the long, stretched-out strings you see in science textbooks. Most of the time, it is stored tight in a package called a nucleosome, wound like a ball of yarn around a protein called chromatin. In order for a gene to be “activated,” the stretch […]

A Nasal Path to Migraine Relief

Roughly 30 million Americans suffer from migraines, and as you might expect, there’s a large pharmaceutical market to prevent or stop these debilitating headaches. Drugs such as Imitrex and Verapamil employ different pharmacological modes of action, reducing migraines by adjusting neurotransmitter levels, blocking ion channels, or simulating the body’s natural painkillers. There’s also a less […]

Linkage 7/22: Smarter Dosing and Fossil Diaries

A large portion of medical research is dedicated to designing and testing new and better drugs for treating disease. But what if we could improve treatments with the drugs we already have – and potentially cut costs at the same time? That’s the proposal made in an editorial this week in the Journal of the […]

The Tools of the Human Microbiome

The latest cult favorite in the sphere of human genetics is the microbiome, the genes of the bacterial species that live inside and upon the human body. Because bacterial cells outnumber human cells in an adult by approximately ten to one, and tens of thousands of different species make up the human ecosystem, studying this […]

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