LabBook August 8, 2014

The folks from the American Liver Foundation Chicago, including the fabulous Liver Man, visited August 6 to present the 2014 Liver Cup to the team from our Center for Liver Diseases for raising the most money for Chicago-area hospitals in the annual Liver Life Walk. The UChicago Medicine team raised $5,670, beating out six other hospitals.

The folks from the American Liver Foundation Chicago, including the fabulous Liver Man, visited August 6 to present the 2014 Liver Cup to the team from our Center for Liver Diseases for raising the most money for Chicago-area hospitals in the annual Liver Life Walk. The UChicago Medicine team raised $5,670, beating out six other hospitals.

This week’s rundown of recent research publications of note from University of Chicago scientists and physicians:

Feasibility and Effectiveness of a Community-Based Smoking Cessation Intervention in a Racially Diverse, Urban Smoker Cohort: including Andrea King, PhD — American Journal of Public Health

From the abstract: “We evaluated the feasibility, acceptability, and effectiveness, in addition to the effects of a psychoeducation-based orientation on smoking cessation knowledge for Courage to Quit (CTQ), an evidence-based smoking cessation intervention disseminated to racially diverse, urban community sites in Chicago, Illinois … CTQ is moderately successful in the short term as delivered in community-based settings for urban-dwelling, largely minority smokers.”

Targeted therapies: Redefining the primary objective of phase I oncology trials (review): Mark Ratain, MD — Nature Reviews Clinical Oncology

Excerpt: “Cytotoxic agents are conventionally dosed on the basis of the maximum tolerated dose defined in phase I trials. A study assessing adverse events in over 2,000 patients treated with molecularly targeted agents suggests a need to redefine criteria for dosing of molecularly targeted agents, which should be based on randomized, dose-ranging phase II trials.”

The effect of in-office waiting time on physician visit frequency among working-age adults: Gavin Hougham, PhD, Gregory Ruhnke, MD, MPH — Social Science & Medicine

From the abstract: “Disparities in unmet health care demand resulting from socioeconomic, racial, and financial factors have received a great deal of attention in the United States. However, out-of-pocket costs alone do not fully reflect the total opportunity cost that patients must consider as they seek medical attention. While there is an extensive literature on the price elasticity of demand for health care, empirical evidence regarding the effect of waiting time on utilization is sparse. Using the nationally representative 2003 Community Tracking Study Household Survey, the most recent iteration containing respondents’ physician office visit frequency and estimated in-office waiting time in the United States (N = 23,484), we investigated the association between waiting time and calculated time cost with the number of physician visits among a sample of working-age adults.”

Prior hematologic conditions carry a high morbidity and mortality in patients supported with continuous-flow left ventricular assist devices: including Nir Uriel, MD — The Journal of Heart and Lung Transplantation

From the abstract: “Mechanical support leads to an increased risk of both bleeding and thrombotic events, but little is known about the risk of device support in patients with a baseline predisposition to these events. The aim of this study was to examine outcomes among patients with baseline hematologic conditions who underwent continuous-flow LVAD implantation (CF-LVAD) … Patients with a history of prior hematologic conditions are at high risk for bleeding, thrombotic and neurologic events during device support, leading to early mortality. This case series questions the benefit of CF-LVAD in these patients and the appropriate management with regard to anti-coagulation.”

About Matt Wood (478 Articles)
Matt Wood is a senior science writer for the University of Chicago Medicine and editor of the Science Life blog.
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