LabBook August 22, 2014

UChicago Medicine employees and families marched in the annual Bud Billiken Day Parade on Aug. 9, 2014 (Photo: Bruce Powell)

UChicago Medicine employees and families marched in the annual Bud Billiken Day Parade on Aug. 9, 2014 (Photo: Bruce Powell)

This week’s rundown of recent research publications of note from University of Chicago scientists and physicians:

Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations: including Robert Shenkar, Changbin Shi, Abdul Ghani Mikati, Lingjiao Zhang, Cecilia Austin, Tania Rebeiz and Issam Awad — Genetics in Medicine

From the abstract: “The phenotypic manifestations of cerebral cavernous malformation disease caused by rare PDCD10 mutations have not been systematically examined, and a mechanistic link to Rho kinase–mediated hyperpermeability, a potential therapeutic target, has not been established … We analyzed PDCD10 small interfering RNA–treated endothelial cells for stress fibers, Rho kinase activity, and permeability … These findings define a unique cerebral cavernous malformation disease with exceptional aggressiveness, and they inform preclinical therapeutic testing, clinical counseling, and the design of trials.”

Nfkb1 is a haploinsufficient DNA damage-specific tumor suppressor: D J Voce, A M Schmitt, A Uppal, M E McNerney, G M Bernal, K E Cahill, J S Wahlstrom, A Nassiri, X Yu, C D Crawley, K P White, K Onel, R R Weichselbaum and B Yamini — Oncogene

From the abstract: “NF-κB proteins play a central and subunit-specific role in the response to DNA damage. Previous work identified p50/NF-κB1 as being necessary for cytotoxicity in response to DNA alkylation damage. Given the importance of damage-induced cell death for the maintenance of genomic stability, we examined whether Nfkb1 acts as a tumor suppressor in the setting of alkylation damage … These data indicate that Nfkb1 is a haploinsufficient, pathway-specific tumor suppressor that prevents the development of hematologic malignancy in the setting of alkylation damage.”

Cost-effectiveness of alternative strategies for integrating MRI into breast cancer screening for women at high risk: including Y-C T Shih — British Journal of Cancer

From the abstract: “Magnetic resonance imaging (MRI) is recommended for women at high risk for breast cancer. We evaluated the cost-effectiveness of alternative screening strategies involving MRI … The high costs of MRI and its lower specificity are limiting factors for annual screening schedule of MRI, except for women at sufficiently high risk.”

Donor Height in Combination With Islet Donor Score Improves Pancreas Donor Selection for Pancreatic Islet Isolation and Transplantation: L.J. Wang, O. Cochet, X.J. Wang, A. Krzystyniak, R. Misawa, K. Golab, M. Tibudan, R. Grose, O. Savari, J.M. Millis, P. Witkowski — Transplantation Proceedings

From the abstract: “To maximize the islet isolation yield for successful islet transplantation, the key task has been to identify an ideal pancreas donor. Since implementation of the islet donor score in donor selection, we have consistently obtained higher islet yields and transplantation rates. In this study, we tested whether assessing donor height as an independent variable in combination with the donor score could improve the pancreas donor selection.”

About Matt Wood (468 Articles)
Matt Wood is a senior science writer for the University of Chicago Medicine and editor of the Science Life blog.
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