LabBook December 12, 2014

The man with the big red shoes himself was on hand today to dedicate the new Ronald McDonald Family Room in Comer Children's Hospital. Ronald McDonald House Charities made a generous donation to renovate the 2nd floor lounge and turn an office into an additional sleep room, for a total of 8 rooms where parents can spend the night.

The man with the big red shoes himself was on hand this week to dedicate the new Ronald McDonald Family Room in Comer Children’s Hospital. Ronald McDonald House Charities made a generous donation to renovate the 2nd floor lounge and turn an office into an additional sleep room, for a total of 8 rooms where parents of patients can spend the night.

This week’s rundown of recent research publications of note from University of Chicago scientists and physicians:

How to Achieve Health Equity: Marshall Chin — New England Journal of Medicine

Editorial: “Two studies in this issue of the Journal indicate that differences in how we deliver care to patients in various racial or ethnic groups have narrowed nationally, but health outcomes remain worse for blacks than for whites … These divergent findings illustrate that reducing racial and ethnic disparities in health outcomes is more difficult than simply standardizing the care provided to patients. Indeed, although it is a positive step that improvements are being made in processes of care in hospitals, providing standardized care for a limited set of inpatient measures is unlikely to lead to equity in health outcomes.”

Integrative analysis of Head and Neck Cancer identifies two biologically distinct HPV and three non-HPV subtypes: including Ravi Salgia, Ralph Weichselbaum, Kevin White, Everett Vokes, and Tanguy Seiwert — Clinical Cancer Research

From the abstract: “Current classification of head and neck squamous cell carcinomas (HNSCC) based on anatomic site and stage fails to capture biologic heterogeneity or adequately inform treatment … Our five-subtype classification provides a comprehensive overview of HPV(+) as well as HPV(-) HNSCC biology with significant translational implications for biomarker development and personalized care for HNSCC patients.”

Emotional intelligence and impulsive aggression in Intermittent Explosive Disorder: including Emil Coccaro — Journal of Psychiatric Research

From the abstract: “Emotional intelligence (EI) relates to one’s ability to recognize and understand emotional information and then, to use it for planning and self-management. Given evidence of abnormalities of emotional processing in impulsively aggressive individuals, we hypothesized that EI would be reduced in subjects with Intermittent Explosive Disorder … the relationship between IED and Strategic EI was fully accounted for by a dimension of hostile cognition defined by hostile attribution and hostile automatic thoughts.”

Protein A-neutralizing monoclonal antibody protects neonatal mice against Staphylococcus aureus: including Olaf Schneewind — Vaccine

From the abstract: “Staphylococcus aureus is a cause of sepsis and meningitis in very-low-birth-weight (VLBW) infants. Clinical trials with S. aureus specific antibodies failed to protect VLBW neonates, which may be due to the immune evasive attributes of staphylococcal protein A (SpA). Here we show that mouse monoclonal antibody SpAKKAA-mAb 3F6, which neutralizes the immunoglobulin Fcγ-binding and B cell receptor crosslinking attributes of SpA, protects neonatal mice against S. aureus sepsis and raises protective immunity against subsequent staphylococcal infection. We developed a humanized SpAKKAA-mAb that protects neonatal mice against S. aureus sepsis and may therefore be subjected to clinical testing in VLBW neonates.”

About Matt Wood (506 Articles)
Matt Wood is a senior science writer at the University of Chicago Medicine and nonfiction editor for Another Chicago Magazine.
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