LabBook January 9, 2015

After a fluffy snow on the Main Quadrangle Tuesday, Jan. 6, 2015, on the University of Chicago campus.    (Robert Kozloff/The University of Chicago)

After a fluffy snow on the Main Quadrangle Tuesday, Jan. 6, 2015, on the University of Chicago campus. (Robert Kozloff/The University of Chicago)

This week’s rundown of recent research publications of note from University of Chicago scientists and physicians:

Ethical Obligations and Clinical Goals in End-of-Life Care: Deriving a Quality-of-Life Construct Based on the Islamic Concept of Accountability Before God (Taklīf): Aasim Padela — American Journal of Bioethics

From the abstract: “End-of-life medical decision making presents a major challenge to patients and physicians alike. In order to determine whether it is ethically justifiable to forgo medical treatment in such scenarios, clinical data must be interpreted alongside patient values, as well as in light of the physician’s ethical commitments. Though much has been written about this ethical issue from religious perspectives (especially Christian and Jewish), little work has been done from an Islamic point of view … we suggest that a Muslim physician is not obligated to maintain or continue clinical treatment when patients who were formerly of, or had the potential to be, mukallaf (the term for a person who has taklīf), are now not expected to regain that status by means of continued clinical treatment.”

Preventive care in older cancer survivors: William Dale — Journal of Geriatric Oncology

From the abstract: “We analyzed a nationally representative sample of 12,458 older adults from the 2003 Medicare Current Beneficiary Survey. Factors associated with non-receipt of preventive care were explored among cancer and non-cancer survivors … Although older cancer survivors are more likely to receive preventive care services than other older adults, factors other than health status considerations (e.g., education, rural residence) are associated with non-receipt of preventive care services.”

Early Life Physical Activity Reverses Metabolic and Foxo1 Epigenetic Misregulation Induced by Gestational Sleep Disturbance: Vesco Mutskov, Abdelnaby Khalyfa, Yang Wang, Alba Carreras, Marcelo Nobrega, David Gozal — American Journal of Physiology

From the abstract: “Sleep disorders are highly prevalent during late pregnancy and can impose adverse effects such as pre-eclampsia and diabetes. However, the consequences of fragmented sleep (SF) on offspring metabolism and epigenomic signatures are unclear. We report that physical activity during early life, but not later, reversed the increased body weight, altered glucose and lipid homeostasis, and increased visceral adipose tissue in offspring of mice subjected to gestational SF.”

The experience of aggressive outbursts in Intermittent Explosive Disorder: Emil Coccaro — Psychiatry Research

From the abstract: “Conceptualizations of Intermittent Explosive Disorder (IED) have suffered from a scarcity of research investigating the subjective experience and phenomenology of the aggressive outbursts among those with IED relative to those who partake in more normative forms of aggression. Furthermore, though some studies have shown that individuals with IED are more impaired and have a poorer quality of life, few studies looked at negative outcomes specific to an individual with IED׳s aggressive behavior. The purpose of this study was to examine the subjective experience and social, occupational, and legal consequences of aggressive outbursts in IED … Results indicated that before and during aggressive outbursts, individuals with IED experienced more intense anger, physiological reactivity, and feelings of dyscontrol as well as more remorse after an aggressive outburst. Furthermore, individuals with IED report more negative consequences of their aggressive outbursts.”

Concentrations of 6-thioguanine nucleotide correlate with trough levels of infliximab in patients with inflammatory bowel disease on combination therapy: Andres Yarur — Clinical Gastroenterology and Hepatology

From the abstract: “In patients with inflammatory bowel diseases (IBD), the combination of infliximab and thiopurines (such as 6-thioguanine) is more effective than monotherapy. We assessed the correlation between serum levels of 6-thioguanine (6-TGN) and infliximab levels or antibodies to infliximab (ATI) … Whereas 6-thioguanine levels of >230 pmol/8×108 RBC have been associated with improved outcomes in patients on monotherapy, a level of 6-thioguanine ≥125 pmol/8×108 RBC may be adequate to achieve therapeutic levels of infliximab. In the long term, this may minimize the toxicity for patients on combination therapy.”

About Matt Wood (478 Articles)
Matt Wood is a senior science writer for the University of Chicago Medicine and editor of the Science Life blog.
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