New analysis finds successes, gaps in community-based diabetes prevention programs

Programs that focused on both diet and exercise were most successful in a community setting.

Programs that focused on both diet and exercise were most successful in a community setting.

Clinical trials conducted in controlled research settings have shown strong evidence that lifestyle interventions can prevent or delay the onset of diabetes. The gold standard for such trials is the Diabetes Prevention Program, which was launched by the National Institutes of Health in 2002. That study included more than 3,200 participants, nearly half of whom represented minority groups. Participants who received intensive counseling about diet and exercise cut their risk of diabetes by half. Those who took oral medications cut their risk by one-third.

Since then, many research studies have implemented similar prevention programs in real-world community settings. In a new report supported by the New York State Health Foundation and the Robert Wood Johnson Foundation, University of Chicago Medicine researchers evaluate the effectiveness of this broad range of programs at reducing the risk or delaying the onset of diabetes.

The report analyzes evidence from 46 studies that used interventions such as diet, exercise or medication to prevent or delay diabetes in at-risk participants. The findings showed comprehensive, community-based programs that included both exercise programs and diet counseling were more effective than those that used a single approach, or even those that administered medication alone.

Chia-Hung Chou, PhD

Chia-Hung Chou, PhD

“This report shows that it is still worth pursuing these diabetes prevent programs in the community,” said lead author Chia-Hung Chou, PhD, research associate/assistant professor in the Section of General Internal Medicine. “However, before we really pour a lot of money into them, we want to know more about how they should be structured, how they can be adapted to different settings and how we can include more participants from the most vulnerable populations.”

Type 2 diabetes is the most common form of the disease, yet it is preventable. It already affects more than 29 million Americans—almost 1 in 10—and the Centers for Disease Control and Prevention projects this to increase to 1 in 5 Americans by 2050. Prevalence of diabetes is particularly high among racial and ethnic minority groups. Native Americans are twice as likely to have diabetes as non-Hispanic whites, while African-Americans and Hispanics are 1.7 times as likely.

While most diabetes prevention programs were moderately successful at reducing the risk for developing the disease, the researchers found that only four studied primarily African-American or Hispanic subjects, despite the high prevalence of the disease in those communities. Lack of standardization in the implementation and documentation of such programs also makes it difficult to assess their costs and long-term effectiveness.

The report authors calculated how likely each intervention program was to reduce the risk of developing diabetes compared with other studies. The analysis found:

  • 23 studies, or 50 percent, implemented full lifestyle interventions of both physical activity and diet; 19 studies, or 41 percent, focused on treatment with medications. The remaining four studies, or 9 percent, introduced diet or physical activity only. Only four of the studies included primarily African-American or Hispanic subjects.
  • There is modest evidence that full lifestyle interventions, including both diet modifications and exercise, can reduce the risk of diabetes. Meanwhile such programs typically can be modified to take place in groups.
  • Programs that focused on either diet or exercise, but not both, do not show much promise for preventing diabetes. Full lifestyle interventions were also more successful than those using medications.
  • Long-term effects of such programs are unclear, due to lack of resources for follow-up.
  • Average costs for the programs are also unclear due to a lack of standardization in study design and documentation.
  • All of the studies that were assessed took place between 2002 and 2013.

To address these gaps, the report’s authors urge health care policymakers to support larger studies assessing the effectiveness of full lifestyle intervention programs in community settings, with a particular focus on recruiting participants from racial and ethnic minority populations that are most vulnerable. The group also recommends further efforts to standardize the design and documentation of community-based prevention programs in order to evaluate their results more consistently and ease implementation in varied settings.

“It may not be possible to ask different research groups to implement prevention programs in a uniform, standardized way,” said Chou. “However, if they are able to follow the same procedure to report their findings and document their study’s implementation and costs, then we will have enough information to know how that program can be implemented again. If we know which parts worked and which parts didn’t, other groups in similar communities can learn from them.”

Additional authors on the report include Deborah Burnet, MD, MA, professor of medicine and pediatrics and Chief of the Section of General Internal Medicine; David Meltzer, MD, PhD, professor of medicine, Chief of the Section of Hospital Medicine, and Director of the Center for Health and the Social Sciences; and Elbert Huang, MD, MPH, associate professor of medicine, Director of the Center for Translational and Policy Research of Chronic Diseases, and Associate Director of the Chicago Center for Diabetes Translation Research.

About Matt Wood (507 Articles)
Matt Wood is a senior science writer at the University of Chicago Medicine and nonfiction editor for Another Chicago Magazine.
%d bloggers like this: