nejm

Reversals of Fortune and Misfortune

July 19, 2011

Salt is bad for you. According to a 2010 article in the New England Journal of Medicine, lowering dietary salt intake by 3 grams per day could “reduce the annual number of deaths from any cause by 44,000 to 92,000.” Or maybe not. A 2011 [Read more]

Treating Height as a Symptom

April 4, 2011

In taking care of sick patients, clinicians have two goals: treating the disease and treating the symptoms. In the case of an infection or a chronic illness, accomplishing this dual purpose is relatively straightforward. But what about when the [Read more]

A Big Leap for Neuroblastoma

September 30, 2010

Cancer successes are usually measured in months, not years. Large clinical trial on promising new treatments are celebrated when they show an average effect of a dozen weeks, and extension of life that can be measured in years is cause for rapture. [Read more]

The Promise of a Near-Miss

May 26, 2010

A critical step in the design of any clinical trial is picking the right primary endpoint, the result that will usually make or break the study. That’s more difficult than it sounds – one’s hope is to cure a disease or relieve a [Read more]